You Should Know
Recurrent Q & A
Questions for Dr.
Diagnosis: Types of Tumors
Epithelial Cancer: Endometrioid carcinoma|
These tumors are most common in the fifth and sixth decades, and the mean patient age is 56 years. The most common symptoms are abdominal distention and pelvic or abdominal pain. Abnormal vaginal bleeding is also frequent. Most patients have an adnexal mass on pelvic examination. It has often been stated that endometrioid carcinomas of the ovary have a better prognosis than typical serous carcinomas of the ovary. However, this is largely if not completely due to the high proportion of cases presenting in stage I. When stratified by stage, all subtypes of ovarian carcinoma have a similar prognosis. The apparent favorable prognosis may also be due, in part, to a high proportion of grade I cases, although data on the influence of grade on prognosis are less clear. Treatment for endometrioid carcinoma is generally the same as that for other ovarian carcinomas. However, progestational agents, antiestrogens, tamoxifen, and other hormonal therapies have been used with limited success in previously treated endometrioid carcinomas; 10-15% response rates have been reported. There may be a correlation between the presence of steroid hormone receptors in tumor tissue and response rates, but data are limited. Hormonal therapy may be a viable option for treatment of recurrence in patients who have failed or cannot tolerate chemotherapy or surgery.