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Diagnosis: Types of Tumors

Epithelial Cancer: Clear cell carcinoma
Clear cell carcinomas comprise 2.4% of ovarian epithelial neoplasms and 7.4% of ovarian carcinomas. The mean age of patients with clear cell carcinoma is 57 years. Symptoms usually relate to a pelvic or abdominal mass. Clear cell carcinoma is the most common epithelial ovarian neoplasm to be associated with paraneoplastic hypercalcemia. There are conflicting data on the behavior of clear cell carcinoma of the ovary. In some studies, the prognosis appears similar to that for other ovarian carcinomas, but in others, the prognosis is said to be worse. In two studies in which analyses were stratified by stage, clear cell carcinoma had a significantly worse prognosis than serous carcinoma only in stage III, based on a total of 81 stage III patients with clear cell carcinoma in these studies. In summary, when controlled for stage, survival of women with clear cell carcinoma may be slightly lower than that of patients with serous carcinoma, but in most analyses, this difference is not statistically significant. The treatment for clear cell carcinoma is similar to that of other epithelial cell types of ovarian carcinoma. Of note, one large series found that women with clear cell carcinoma treated with platinum-based chemotherapy were at significantly increased risk of thromboembolic complications compared to those with non-clear cell carcinomas.

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