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You Should Know
Anatomy
Prevention
Risk Factors
Genetics
Screening
CA 125
Symptoms
Early Detection
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Pathologists
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Glossary
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Questions for Dr.
Diagnosis: Types of Tumors  |
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Atypical proliferative ("borderline") mucinous tumors, gastrointestinal type Back |
| APMTs are benign, with survival rates of 98-99% based on literature reviews including approximately 900 patients. Very rare reports of aggressive behavior most likely reflect inadequate sampling with failure to detect occult invasion, or the ovarian tumor may be a metastasis from an occult primary source elsewhere. Although the literature suggests that the survival of patients with advanced stage MBTs is only 54%, it is now clear that bona fide advanced stage MBT rarely if ever occurs. Eighty-six percent of women who have been reported to have advanced stage MBTs present with the syndrome of pseudomyxoma peritonei, a condition which is not of ovarian origin. |
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Mucinous tumors associated with pseudomyxoma peritonei |
| PMP is nearly always of gastrointestinal origin, usually from a mucinous adenoma of the vermiform appendix. The behavior of mucinous tumors associated with PMP depends on tumor morphology. Cases designated DPAM are nearly always associated with appendiceal mucinous adenomas and constitute the classic description of pseudomyxoma peritonei found in the older literature, in which the behavior is characterized as slowly progressive, with reaccumulation of mucinous ascites, and compatible with prolonged survival if treated symptomatically by periodic evacuation of the ascites. The five-year survival rate is 84%. In contrast, those cases characterized by morphological features of carcinoma, designated PMC, are metastatic mucin-secreting carcinomas from the appendix or colon and are associated with an aggressive clinical course, with over 90% of patients dead within three years. The latter group, by morphology and behavior, are high grade carcinomas. |
